This compound and (—)-kaur-16-en-19-oic acid are considered biosynthetic precursors of stevioside (1) (Hanson and White 1968) In another biosynthetic study Alves and Ruddat (1979) isolated gibberellin A20 from the stems and leaves of S rebaudiana and proposed that steviol (7) may be a precursor for C-13 hydroxy-gibberellins Labdane • Study of aerial parts yielded four new labdane-derived diterpenes and scopanolal (5) along with two known diterpenes dulcinol/scopadulciol (3) and scopadiol (6) (see study below) (47) • Study of four crude extracts yielded the presence of alkaloid saponin tannin and flavonoid 48) • Preliminary phytochemical analysis of ethanolic root and leaves extract yielded tannins

Quantification of Thiamethoxam in Rhizomes and Leaves

The linearity stability accuracy and inter-day precisions of the assay method were evaluated in water soil and rhizomes and leaves of Hedychium coronarium of the Zingiberaceae family Mato Grosso do Sul is a predominantly agricultural state in Brazil and has many rivers and permanent and seasonal lakes in which the Hedychium coronarium an aquatic plant is found the swampy environments

Juice or an infusion of fresh leaves is given to infants to relieve griping irregular bowel habits and loss of appetite Leaves and root are also used in general debility during convalescence after fevers for dyspepsia associated with gaseous distension and in advanced stages of dysentery In China the herb derived from the leaves or aerial parts of Andrographis paniculata is known as

Cistus creticus subsp creticus is a plant of intrinsic scientific interest due to the distinctive pharmaceutical properties of its resin Labdane-type diterpenes the main constituents of the resin exhibit considerable antibacterial and cytotoxic activities In this study chemical analysis of isolated trichomes from different developmental stages revealed that young leaves of 1–2 cm length

- Study of aerial parts yielded two new furanoditerpene-lactones LS-1 (1) and LS-2 (2) along with four known furanoditerpene-lactones 3 4 5 and 6 (see studies below) 7) - Methanolic extract of aerial parts yielded two new phenols yimunoside A and yimunol A together with eight known compounds: 4-hydroxythiophenol syringic acid apigenin luteolin-7-methylether genkwanin isoquercitrin

Carnosic acid and carnosol in leaves of rosemary plants (Sudbury Blue variety) grown under two different conditions of light and temperature (250 μmol photons m −2 s −1 at 25C/15C day/night [control] or 1 200 μmol photons m −2 s −1 at 35C/5C [stress]) A Carnosic acid carnosol α-tocopherol and plastochromanol-8 concentrations in leaves DW Dry weight Asterisks indicate

Monograph amr

aerial parts 17 18 Two new flavonoid glycosides and a new diterpenoid (andrographic acid) were recently reported 19 and two new ent-labdane diterpenoid glycosides were isolated from the aerial parts 20 Mechanisms of Action Hepatoprotective E!ects A paniculata is extensively used as a hepatostim-ulant and hepatoprotective agent in Indian systems of medicine 21 A paniculata is also an

Seven labdane‐type diterpenes coronarin E coronarin A yunnancoronarin A yunnancoronarin B hedyforrestin B villosin and hedyforrestin C were isolated from the rhizome of Hedychium gardnerianum and evaluated for cytotoxic activity against human small cell lung cancer (NCI‐H187) and non‐cancerous Vero cells The results showed that villosin exhibited potent cytotoxic activity with

Diterpenes glycosides reported in this plant are 3-O-beta-D-glucosyl-14-deoxyandrographiside and 3-O-beta-D-glucosyl-14-deoxy-11 12-didehydroandrographiside [25] Deoxyandrographolide-19-beta-D-glucoside a diterpene glucoside from leaves six diterpenoids of the ent-labdane type two diterpene glucosides and four diterpene dimers (bis-

The antibacterial activity of seven labdane-type diterpenes is reported Five were isolated from the resin of the plant Cistus creticus from which 13(E)-labd-13-ene 8α-ol-15-yl malonic acid (5) 1 is a new natural product while the two others were hemisynthetic derivatives Key Words: Cistus creticus Cistaceae labdane diterpenes antibacterial activity Article Metrics Views 93 Citations

Two New Labdane Diterpenes from Fresh Leaves of Leonurus japonicus and Their Degradation during Drying Hiroyuki Fuchino * a Akihiro Daikonya a Takeo Kumagai Yukihiro Goda b Yutaka Takahashi c and Nobuo Kawaharaa a Research Center for Medicinal Plant Resources National Institute of Biomedical Innovation 1–2 Hachimandai Tsukuba Ibaraki 305–0843 Japan: b Division of

- Study of aerial parts yielded seven new diterpenes sibiricinones A-E and 15-epi-sibiricinones D and E and the flavone genkwanin ( 20 ) - LC-MS/MS and HPLC analyses yielded nine phenolic compounds: catechin verbascoside two flavonoids (quercetin and rutin) and five phenolic acids (4-hydroxybenzoic acid chlorogenic acid caffeic acid p-coumaric acid and ferulic acid

After field bioassay suggested that fresh leaves of Cornutia grandiflora were highly repellent to the leafcutter ant Acromyrmex octospinosus (Reich) two novel neo-clerodane diterpenoids cornutins A and B (34 49) were isolated displaying a unique ether linkage spanning C-1 and C-12 [32] Cornutins C-L 36a-40 have been more recently isolated from

Croton zambesicus and only clerodane labdane and trachylobane diterpenes have been isolated from the stem bark of this plant (Ngadjui et al 2002) Recently however we have isolated new cytotoxic pimarane and trachylobane diterpenes from a dichloromethane extract of the leaves of C zambesicus (Block et al 2002 2004)

US Patent for Composition of labdane diterpenes

Composition of labdane diterpenes extracted from andrographis paniculata useful for the treatment of autoimmune diseases and alzheimer disease by activation for PPR-gamma receptors May 21 2004 The diterpenic labdane 3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5 ha-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-dihydro-4-hydroxy-2(3h)-furanone chemically diagrammed as inhibits the

new bioactive molecules of natural origin" ΙV IKYDA- 2007 "Antiinflammatory cytostatic activity of labdane diterpenes from Greek endemic Lamiaceae" (2007 2008) V 2007-2014 - Department of Pharmaceutical Sciences University of Florence: 2007-2009: Phytotherapeutics and health products of plant origin: screening of new matrixes and technological studies for the improvement of their

As a result leojaponic acids A (1 C17H24O4) and B (2 C18H26O4) two homologous terpenoids together with (-)-loliolide (3) 1-(3-ethylphenyl) ethane-1 2-diol (4) and dibutyl phthalate (5) were isolated from the EtOH extract of L japonicus All the chemical structures of the isolates were elucidated on the basis of 1D and 2D NMR analyses Compounds 1 and 2 were new terpenoids and

27 12 2011Composition of labdane diterpenes extracted from andrographis paniculata useful for the treatment of autoimmune diseases and alzheimer disease by activation for PPR-gamma receptors United States Patent 8084495 Abstract: The diterpenic labdane 3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5 ha-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-dihydro-4-hydroxy-2(3h)

Diterpenes glycosides reported in this plant are 3-O-beta-D-glucosyl-14-deoxyandrographiside and 3-O-beta-D-glucosyl-14-deoxy-11 12-didehydroandrographiside [25] Deoxyandrographolide-19-beta-D-glucoside a diterpene glucoside from leaves six diterpenoids of the ent-labdane type two diterpene glucosides and four diterpene dimers (bis-

01 03 2015Our previous investigation on two plants of the family of Lamiaceae resulted in the isolation of a number of new labdane diterpenes (Wu et al 2011 Wu et al 2013) In our research on psychoactive natural products from L japonicus two diterpenoids were isolated and identified

Chen LX Feng Q Hong W Qu GX and Yao XS Nine new ent-labdane diterpenoids from the aerial parts of Andrographis paniculata Helvetica Chimica Acta 2006 89:2654-2664 Chen L Zhu H Wang R Zhou K Jing Y Qiu F ent-Labdane diterpenoid lactone stereoisomers from Andrographis paniculata Journal of Natural Products 2008 71(5):852-855

Seven labdane‐type diterpenes coronarin E coronarin A yunnancoronarin A yunnancoronarin B hedyforrestin B villosin and hedyforrestin C were isolated from the rhizome of Hedychium gardnerianum and evaluated for cytotoxic activity against human small cell lung cancer (NCI‐H187) and non‐cancerous Vero cells The results showed that villosin exhibited potent cytotoxic activity with

22 09 1997Nine new labdane diterpenes (1 4−11) and two known diterpenes have been isolated from the aerial parts of the medicinal plant Alpinia chinensis Their structures were determined from 2D NMR spectroscopy Biogenetic relationships among these terpenoids are discussed

Labdane-derived diterpenes iso-dulcinol 4-epi-scopadulcic acid B dulcidiol and scopanolal together with two known diterpenes dulcinol/scopadulciol and scopadiol which were isolated from the aerial parts of Scoparia dulcis Linn Cytotoxicity against a panel of six human stomach cancer cell lines were proved in the crude extracts of Scoparia dulcis Linn (Ahsan et al 2003) Scoparia dulcis

Two New Labdane Diterpenes from Fresh Leaves of Leonurus japonicus and Their Degradation during Drying Hiroyuki Fuchino 1) Akihiro Daikonya 1) Takeo Kumagai 1) Yukihiro Goda 2) Yutaka Takahashi 3) Nobuo Kawahara 1) 1) Research Center for Medicinal Plant Resources National Institute of Biomedical Innovation 2) Division of Pharmacognosy Phytochemistry and Narcotics National